{"id":69,"date":"2025-08-29T04:46:17","date_gmt":"2025-08-29T04:46:17","guid":{"rendered":"https:\/\/shining-biotech.breadnbutteryilan.com\/?page_id=69"},"modified":"2026-04-29T10:29:50","modified_gmt":"2026-04-29T02:29:50","slug":"nk%e7%b4%b0%e8%83%9e%e8%a3%bd%e5%8a%91","status":"publish","type":"page","link":"https:\/\/shining-biotech.com\/ja\/nk%e7%b4%b0%e8%83%9e%e8%a3%bd%e5%8a%91\/","title":{"rendered":"NK\u7d30\u80de\u306e\u8abf\u88fd"},"content":{"rendered":"
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\"\"<\/figure>\n\n\n\n

NK\u7d30\u80de\u306e\u8abf\u88fd<\/h2>\n<\/div>\n\n\n\n
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\u81ea\u7136\u6bba\u624b\u7d30\u80de(Natural Killer Cell,NK Cell)\u5728\u764c\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u61c9\u7528<\/a><\/pre>\n\n\n\n
NK\u7d30\u80de\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u91cd\u8981\u306a\u62c5\u3044\u624b\u3067\u3042\u308b\u3002<\/a><\/p>\n\n\n\n\n\n
\u65e5\u672c\u306b\u304a\u3051\u308bNK\u7d30\u80de\u7642\u6cd5\u306e\u73fe\u72b6<\/a><\/p>\n\n\n\n
NK\u7d30\u80de\u3068\u4ed6\u306e\u75be\u60a3\u3068\u306e\u76f8\u95a2\u6027<\/a><\/p>\n\n\n\n
\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068NK\u7d30\u80de\u306e\u95a2\u9023\u6027<\/a><\/p>\n\n\n\n
CD56+\u3092\u767a\u73fe\u3059\u308bNK\u7d30\u80de\u306e\u751f\u7406\u7684\u6027\u8cea<\/a><\/p>\n\n\n\n
TIMO\u306eNK\u7d30\u80de\u306f\u5927\u91cf\u3001\u9ad8\u7d14\u5ea6\u3001\u9ad8\u6d3b\u6027\u3067\u3042\u308b\u3002<\/a><\/p>\n\n\n\n
\u81cd\u5e36\u8840\u8a98\u5c0e\u4e4b NK \u7d30\u80de (CB-NK)<\/a><\/p>\n<\/div>\n\n\n\n
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\u81ea\u7136\u6bba\u624b\u7d30\u80de (Natural Killer Cell,NK Cell) \u5728\u764c\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u61c9\u7528<\/h6>\n\n\n\n
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\u570b\u969b\u91ab\u5b78\u671f\u520a\u767c\u8868\u8a31\u591a\u7814\u7a76\u6307\u51fa\uff0cNK \u7d30\u80de\u5c0d\u65bc\u591a\u7a2e\u5be6\u9ad4\u816b\u7624\u5177\u6709\u986f\u8457\u7684\u6bd2\u6bba\u6548\u679c\uff0c\u50cf\u662f\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u3001\u814e\u81df\u764c\u3001\u5927\u8178\u76f4\u8178\u764c\u3001\u80c3\u764c\u3001\u809d\u764c\u3001\u4e73\u764c\u3001\u80ba\u764c\u7b49\uff0c\u5e7e\u4e4e\u6db5\u84cb\u6240\u6709\u816b\u7624\uff0c\u7814\u7a76\u4e2d\u4e5f\u767c\u73fe\u5468\u908a\u8840\u6db2\u7684 NK \u7d30\u80de\u6d3b\u6027\u4f4e\u4e0b\u8207\u6210\u4eba\u764c\u75c7\u98a8\u96aa\u589e\u52a0\u4e4b\u9593\u5b58\u5728\u95dc\u806f\u60271<\/a><\/span>\u3002<\/pre>\n\n\n\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
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NK\u7d30\u80de\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u91cd\u8981\u306a\u62c5\u3044\u624b\u3067\u3042\u308b\u3002<\/h6>\n\n\n\n
NK \u7d30\u80de\u5728\u514d\u75ab\u7cfb\u7d71\u4e2d\uff0c\u662f\u6709\u91cd\u8981\u6bd2\u6bba\u80fd\u529b\u7684\u7d30\u80de\uff0c\u7d04\u4f54\u6240\u6709\u6dcb\u5df4\u7403\u7684 5-15%\uff0c\u4e3b\u8981\u5206\u4f48\u65bc\u5468\u908a\u8840\u53ca\u813e\u81df\uff0c\u5177\u6709\u975e\u5c08\u4e00\u6027\u7d30\u80de\u6bd2\u6bba\u4f5c\u7528\uff0c\u53ef\u6d88\u6ec5\u591a\u7a2e\u75c5\u539f\u9ad4\u53ca\u816b\u7624\u7d30\u80de\uff0c\u7576 NK \u7d30\u80de\u63a5\u89f8\u4e0d\u6b63\u5e38\u7d30\u80de\u6642\uff0c\u6703\u91cb\u51fa\u7a7f\u5b54\u7d20 (perforin) \u4f7f\u7d30\u80de\u819c\u7834\u88c2\u9032\u800c\u6bba\u6b7b\u75c5\u539f\u9ad4\u6216\u816b\u7624\u7d30\u80de2<\/a><\/span>\u3002<\/pre>\n<\/div>\n\n\n\n\n\n
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\u65e5\u672c\u306b\u304a\u3051\u308bNK\u7d30\u80de\u7642\u6cd5\u306e\u73fe\u72b6<\/h6>\n\n\n\n\n\n\n\t\n\n\t\n\t
 <\/th>\u6df1\u523b\u306a\u5371\u967a\u306b\u3055\u3089\u3055\u308c\u3066\u3044\u308b\u60a3\u8005
\n(\u9032\u884c\u304c\u3093\uff1a\u30b9\u30c6\u30fc\u30b83\uff5e4\uff09<\/th>		\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u60a3\u8005
\n(\u304c\u3093\u30d5\u30a7\u30fc\u30ba0\uff5e2\uff09<\/th>		\u96c6\u4e2d\u6cbb\u7642\u306e\u5f8c
\n\u4e0d\u826f\u671f\u9593<\/th>\n<\/tr>\n<\/thead>\n
\u91dd\u306e\u672c\u6570<\/td>\u9023\u7e8c10\u91dd\uff0c\u6bcf10\u91dd\u6bd4\u8f03\u6cbb\u7642\u524d\u5f8c\u7d50\u679c<\/td>\u9023\u7e8c6-8\u91dd\uff0c\u6bcf4\u91dd\u6bd4\u8f03\u6cbb\u7642\u524d\u5f8c\u7d50\u679c<\/td>\u500b\u4eba\u306b\u5fc5\u8981\u306a\u937c\u306e\u6570\u306f\u3001\u5e0c\u671b\u3059\u308b\u7d50\u679c\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u3002<\/td>\n<\/tr>\n
\u983b\u5ea6<\/td>1\u9031\u9593\u3054\u3068\u306b2\u56de\uff08\u307e\u305f\u306f\u305d\u308c\u4ee5\u4e0a\uff09\u306e\u6ce8\u5c04\u3092\u884c\u3046\u96c6\u4e2d\u6cbb\u7642\u671f\u9593\u3001\u7d4c\u904e\u89b3\u5bdf\u5f8c\u3001\u7dad\u6301\u671f\u9593\u306b\u5165\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u3002<\/td>1\u9031\u9593\u3054\u3068\u306e\u96c6\u4e2d\u6cbb\u7642\u671f\u9593 \u6ce8\u5c041\u56de\u3001\u7d4c\u904e\u89b3\u5bdf\u5f8c\u3001\u7dad\u6301\u671f\u9593\u306b\u5165\u308b\u304b\u3069\u3046\u304b\u6c7a\u5b9a<\/td>4\u9031\u9593\u3054\u3068\u306b1\u56de\u3001\u56db\u534a\u671f\u3054\u3068\u306b1\uff5e3\u56de\u306b\u5897\u3084\u3057\u3001\u7d4c\u6e08\u7684\u306b\u8a31\u305b\u3070\u3001\u5e74\u95936\uff5e8\u56de\u4ee5\u4e0a\u6ce8\u5c04\u3059\u308b\u306e\u304c\u3088\u3044\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n\n\n
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NK\u7d30\u80de\u3068\u4ed6\u306e\u75be\u60a3\u3068\u306e\u76f8\u95a2\u6027<\/h6>\n\n\n\n
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\"\"<\/figure>\n\n\n\n
\u5728 Mandal A \u8207 Lunemann S \u767c\u8868\u7684\u7814\u7a76\u986f\u793a\uff0cNK \u7d30\u80de\u5c0d\u764c\u75c7\u6cbb\u7642\u6709\u6548\u5916\uff0c\u5728\u5176\u4ed6\u75be\u75c5\u4e5f\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\uff0c\u50cf\u662f\u75c5\u6bd2\u6027\u809d\u708e\u6216\u809d\u529f\u80fd\u7570\u5e38\u4e4b\u56b4\u91cd\u5ea6\u548c NK \u7d30\u80de\u6578\u91cf\u6e1b\u5c11\u76f8\u95dc\uff0c\u9019\u8868\u793a NK \u7d30\u80de\u5728\u9632\u79a6\u75c5\u6bd2\u6027\u809d\u708e\u548c\u809d\u81df\u75be\u75c5\u4e4b\u767c\u75c5\u6a5f\u5236\u6709\u5176\u95dc\u9375\u4f5c\u75283<\/a><\/span>\u3002
\u5728\u8a31\u591a\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u7684\u6848\u4f8b\u4e2d\uff0c\u4f8b\u5982: \u7d05\u6591\u6027\u72fc\u7621\u3001\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u7b49\uff0c\u89c0\u5bdf\u5230 NK \u7d30\u80de\u6578\u91cf\u6e1b\u5c11\u8207\u7d30\u80de\u6bd2\u6bba\u529f\u80fd\u964d\u4f4e\u7684\u73fe\u8c61\uff0c\u63db\u53e5\u8a71\u8aaa\uff0cNK \u7d30\u80de\u53ef\u80fd\u6709\u9810\u9632\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u6216\u662f\u6709\u8abf\u63a7\u8a72\u75be\u75c5\u7684\u4f5c\u75281<\/a><\/span>\u3002<\/pre>\n<\/div>\n<\/div>\n\n\n\n
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\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068NK\u7d30\u80de\u306e\u95a2\u9023\u6027<\/h6>\n\n\n\n
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\"\"<\/figure>\n\n\n\n
\u6839\u64da\u7814\u7a76\u548c\u6587\u737b\u767c\u8868\u986f\u793a\uff0cNK \u7d30\u80de\u6bd2\u6bba\u529f\u80fd\u6703\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\u800c\u964d\u4f4e; \u76f8\u8f03\u65bc\u5e74\u8f15\u4eba\u7684 NK \u7d30\u80de\uff0c\u8001\u5e74\u4eba\u7684 NK \u7d30\u80de\u91cb\u653e\u4e4b\u7a7f\u5b54\u7d20\u8f03\u5c11; \u4ee3\u8868 NK \u7d30\u80de\u6d3b\u6027\u4e4b\u7279\u7570\u6027\u6a19\u8a8c NKp30 \u6216 NKp46 \u7684\u8868\u9054\u91cf\uff0c\u4e5f\u6703\u53d7\u5230\u5e74\u9f61\u589e\u9577\u7684\u5f71\u97ff\u800c\u964d\u4f4e\u3002\u9019\u4e9b\u73fe\u8c61\u986f\u793a\uff0c\u5ef6\u9072\u6216\u9006\u8f49 NK \u7d30\u80de\u8870\u8001\u4f5c\u70ba\u9810\u9632\u6216\u6cbb\u7642\u7b56\u7565\uff0c\u53ef\u80fd\u662f\u6539\u5584\u4e26\u589e\u9032\u8001\u5e74\u4eba\u5065\u5eb7\u7684\u4e00\u7a2e\u65b9\u6cd54<\/a><\/span>\u3002<\/pre>\n<\/div>\n<\/div>\n\n\n\n
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CD56+\u3092\u767a\u73fe\u3059\u308bNK\u7d30\u80de\u306e\u751f\u7406\u7684\u6027\u8cea<\/h6>\n\n\n\n
\u7531\u65e5\u672c\u7684\u6d77\u8001\u540d\u5353\u4e09\u90ce (Takusaburo Ebina) \u91ab\u5e2b\u767c\u8868\u4e4b\u7814\u7a76\u6307\u51fa\uff0c\u514d\u75ab\u7cfb\u7d71\u3001\u5fc3\u7406\u795e\u7d93\u7cfb\u7d71\u548c\u5167\u5206\u6ccc\u7cfb\u7d71\u6703\u5728\u4eba\u9ad4\u4e2d\u4ea4\u4e92\u5f71\u97ff\uff0c\u800c\u8868\u73fe CD56+ \u7684 NK \u7d30\u80de\u5177\u6709\u5f37\u5927\u7684\u7d30\u80de\u6bd2\u6bba\u6d3b\u6027\uff0c\u9664\u4e86\u53ef\u4ee5\u7522\u751f\u6297\u764c\u7684\u7d30\u80de\u56e0\u5b50\uff0c\u5305\u62ec\u5e72\u64fe\u7d20-\u03b3 (interferon-\u03b3\uff0cIFN-\u03b3) \u53ca\u816b\u7624\u58de\u6b7b\u56e0\u5b50-\u03b1 (tumor necrosis factor-\u03b1, TNF-\u03b1)\uff1b\u4e26\u4e14\u53ef\u4ee5\u5206\u6ccc\u5177\u6709\u93ae\u975c\u3001\u93ae\u75db\u529f\u80fd\u7684\u8166\u5167\u5561 (\u03b2-endorphin)\uff0c\u4f7f\u4eba\u7522\u751f\u6109\u6085\u611f\uff0c\u80fd\u660e\u986f\u6539\u5584\u764c\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea5<\/a><\/span>\u3002
\u57fa\u65bc\u8868\u73fe CD56+ \u7684 NK \u7d30\u80de\uff0c\u80fd\u5920\u8abf\u7bc0\u4eba\u9ad4\u4e09\u5927\u7cfb\u7d71\uff1a\u81ea\u5f8b\u795e\u7d93\u3001\u5167\u5206\u6ccc\u53ca\u514d\u75ab\u7cfb\u7d71\uff0c\u56e0\u6b64\u7814\u7a76\u5c07\u5176\u547d\u540d\u70ba\u300c\u795e\u7d93-\u514d\u75ab-\u5167\u5206\u6ccc\u8abf\u7bc0\u7d30\u80de (neuro-immune-endocrine cell)\u300d\uff0c\u9019\u7a2e\u8868\u73fe CD56+ \u7684 NK \u7d30\u80de\u6709\u8457\u8207\u9ad4\u5167\u5e73\u8861\u74b0\u74b0\u76f8\u6263\u7684\u5bc6\u5207\u95dc\u4fc25<\/a><\/span>\u3002<\/pre>\n\n\n\n
\"\"<\/figure>\n<\/div>\n\n\n\n
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TIMO\u306eNK\u7d30\u80de\u306f\u6570\u3001\u7d14\u5ea6\u3001\u6d3b\u6027\u3068\u3082\u306b\u975e\u5e38\u306b\u9ad8\u3044\u3002<\/h6>\n\n\n\n
\"\"<\/figure>\n<\/div>\n\n\n\n
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\u81cd\u5e36\u8840\u8a98\u5c0e\u4e4b NK \u7d30\u80de (CB-NK)<\/h6>\n\n\n\n
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TIMO \u7684\u5e79\u7d30\u80de\u589e\u6b96\u6280\u8853\u4e4b\u512a\u52e2\uff0c\u53ef\u5f9e\u5468\u908a\u8840\u8403\u53d6\u4e26\u589e\u6b96\u5e79\u7d30\u80de\uff0c\u4ea6\u53ef\u5f9e\u81cd\u5e36\u8840\u4e2d\u7684\u9aa8\u9ad3\u9020\u8840\u5e79\u7d30\u80de\u8a98\u5c0e\u4e26\u589e\u6b96\u6210 NK \u7d30\u80de (cord blood-derived NK\uff0cCB-NK)\uff0c\u5728 2 \u9031\u57f9\u990a\u671f\u9593\u589e\u6b96\u500d\u6578\u53ef\u9054\u6578\u5343\u500d\u3002TIMO \u5be6\u9a57\u5ba4\u6578\u64da\u986f\u793a\uff0cCB-NK \u7684\u512a\u52e2\u5728\u65bc\u7d30\u80de\u6d3b\u6027\u70ba\u81ea\u9ad4 NK \u7d30\u80de\u7684 3-5 \u500d\uff0c\u81ea\u9ad4 NK \u7d30\u80de\u53ef\u6bd2\u6bba 5 \u500b\u4ee5\u4e0a\u76ee\u6a19\u7d30\u80de (\u764c\u7d30\u80de\u6216\u75c5\u6bd2\u611f\u67d3\u7d30\u80de)\uff0c\u800c CB-NK \u53ef\u6bd2\u6bba\u9ad8\u9054 50 \u500b\u4ee5\u4e0a\u76ee\u6a19\u7d30\u80de\u3002<\/pre>\n\n\n\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
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\u53c2\u8003\u6587\u732e<\/h6>\n\n\n\n
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1.\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\uff1a\u5065\u5eb7\u3068\u75c5\u6c17\u306b\u304a\u3044\u3066<\/h6>\n\n\n\n
Mandal A, et al. Hematol Oncol Stem Cell Ther. 2015;8:47-55.<\/pre>\n<\/div>\n\n\n\n
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2.\u514d\u75ab\u5b66<\/h6>\n\n\n\n
Roitt I, et al. Immunology, 6th ed., St. Louis: mosby, 2001, p.480.<\/p>\n<\/div>\n\n\n\n
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3. Compromised function of natural killer cells in acute and chronic viral hepatitis<\/h6>\n\n\n\n
Lunemann S, et al. J Infect Dis. 2014;209:1362-73.<\/pre>\n<\/div>\n\n\n\n
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4. The impact of ageing on natural killer cell function and potential consequences for health in older adults<\/h6>\n\n\n\n
Hazeldine J, et al. Ageing Res Rev. 2013;12:1069-78.<\/pre>\n<\/div>\n\n\n\n
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5. Effector mechanism and clinical response of BAK (BRM-activated killer) immuno-cell therapy for maintaining satisfactory QOL of advanced cancer patients utilizing CD56-positive NIE (neuro-immune-endocrine) cells<\/h6>\n\n\n\n
Ebina T, et al. Microbiol Immunol. 2001;45:403-11.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
<\/p>","protected":false},"excerpt":{"rendered":"
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